| Solution Information | help | |
| Enzyme: | cAMP-dependent protein kinase type I-alpha regulatory subunit | |
| inhibitor: | BDBM66980 | |
| substrate: | n/a | |
| Solution Type: | Aqueous | |
| pH at Preparation: | n/a | |
| Temp. Prep.: | n/a | |
| Comments: | Assay Overview: The purpose of this biochemical assay is to determine if compounds identified as active in a set of previous experiments entitled, "Fluorescence polarization-based biochemical primary high throughput screening assay to identify activators of the Protein Kinase A-R2BA (PKA-R2B) complex" (AID 504700), that confirmed activity in a set of experiments entitled, "Fluorescence polarization-based biochemical high throughput confirmation assay for activators of the Protein Kinase A-R2B (PKA-R2B) complex" (AID 504797) and that were inactive in a set of experiments entitled, "Counterscreen for activators of the Protein Kinase A-R2B (PKA-R2B) complex: fluorescence polarization-based biochemical high throughput screening assay to identify fluorescence polarization assay artifacts" (AID 504796) are non-selective due to activation of PKAR1A. In addition compounds showing activation of greater than 10% in a set of experiments entitled, "Fluorescence polarization-based biochemical hig | |
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